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基于绿色化学理念的大学实验教学改革—电化学合成二苯甲酮综合实验设计. (2025). 教育学刊, 3(8), 175-181. https://doi.org/10.62836/
Copyright (c) 2025 战勇, 程朕, 张永红, 金伟伟
This work is licensed under a Creative Commons Attribution 4.0 International License.
基于绿色化学理念的大学实验教学改革—电化学合成二苯甲酮综合实验设计
战勇1,#，程朕2,#，张永红2,*，金伟伟1,*
1. 中国计量大学生命科学学院，浙江杭州；
2. 新疆大学化学学院，新疆乌鲁木齐
摘要：当今世界科技发展迅速，对大学人才培养模式的改革提出了更高的要求。为适应科技创新和高校人才培养模式创新的需求，需要对大学课堂教学内容和教学手段不断进行改革。实验教学是高等教育重要的组成部分，是培养学生动手能力和知识应用能力的主要途径之一。本实验将前沿的电化学合成和流动化学技术引入到大学实验教学改革中，以苯频哪醇为原料，通过氧化裂解反应合成了二苯甲酮化合物。在实验过程中，学生可以学习电化学反应装置的搭建，熟悉电化学反应过程，掌握薄层色谱、柱层析等分离操作，学会用熔点测定和核磁共振波谱对产物进行表征与分析。通过对比电化学和热化学两种合成方法，有助于培养学生独立分析问题的能力，激发学生的创新意识，树立“绿色合成”理念，提升其综合实践能力。
参考文献
[1] Shi, S., Liang, Y. and Jiao N. (2021) Electrochemical Oxidation Induced Selective C–C Bond Cleavage. Chem. Rev., 121, 485-505.
[2] Day, D.P., Vargas, J.A.M. and Burtoloso, A.C.B. (2021) Synthetic Routes Towards the Synthesis of Geminal α-Difunctionalized Ketones. Chem. Rec., 21, 2837-2854.
[3] Sudalai, A., Khenkin, A. and Neumann, R. (2015) Sodium periodate mediated oxidative transforma- tions in organic synthesis. Org. Biomol. Chem., 13, 4374-4394.
[4] Baer, E., Grosheintz, J.M. and Fischer, H.O.L. (1939) Oxidation of 1,2-Glycols or 1,2,3-Polyalcohols by Means of Lead Tetraacetate in Aqueous Solution. J. Am. Chem. Soc., 61, 2607-2609.
[5] Beebe, T.R., Hii, P. and Reinking P. (1981) Oxida- tive cleavage of 1,2-diols with N-iodosuccinimide. J. Org. Chem., 46, 1927-1929.
[6] Kingston, C., Palkowitz, M.D., Takahira, Y., Van- tourout, J.C., Peters, B.K., Kawamata, Y. and Baran, P.S. (2020) A Survival Guide for the "Electro-curi-ous". Acc. Chem. Res., 53, 72-83.
[7] 胡良桢, 倪黎, 牛子怡, 张晓慧, 秦波, 熊燕. 电化学合成二苯甲酮的绿色化学实验[J].大学化学, 2024, 39(6): 350-356.
[8] Wang, R., Sun, P., Jin, W., Zhang, Y., Wang, B.; Xia, Y., Xue, F., Abdukader, A. and Liu, C. (2022) Efficient and eco-friendly oxidative cleavage of C–C bonds of 1,2-diols to ketones: electrochemistry vs thermochemistry. Org. Chem. Front., 9, 2664-2670.
[2] Day, D.P., Vargas, J.A.M. and Burtoloso, A.C.B. (2021) Synthetic Routes Towards the Synthesis of Geminal α-Difunctionalized Ketones. Chem. Rec., 21, 2837-2854.
[3] Sudalai, A., Khenkin, A. and Neumann, R. (2015) Sodium periodate mediated oxidative transforma- tions in organic synthesis. Org. Biomol. Chem., 13, 4374-4394.
[4] Baer, E., Grosheintz, J.M. and Fischer, H.O.L. (1939) Oxidation of 1,2-Glycols or 1,2,3-Polyalcohols by Means of Lead Tetraacetate in Aqueous Solution. J. Am. Chem. Soc., 61, 2607-2609.
[5] Beebe, T.R., Hii, P. and Reinking P. (1981) Oxida- tive cleavage of 1,2-diols with N-iodosuccinimide. J. Org. Chem., 46, 1927-1929.
[6] Kingston, C., Palkowitz, M.D., Takahira, Y., Van- tourout, J.C., Peters, B.K., Kawamata, Y. and Baran, P.S. (2020) A Survival Guide for the "Electro-curi-ous". Acc. Chem. Res., 53, 72-83.
[7] 胡良桢, 倪黎, 牛子怡, 张晓慧, 秦波, 熊燕. 电化学合成二苯甲酮的绿色化学实验[J].大学化学, 2024, 39(6): 350-356.
[8] Wang, R., Sun, P., Jin, W., Zhang, Y., Wang, B.; Xia, Y., Xue, F., Abdukader, A. and Liu, C. (2022) Efficient and eco-friendly oxidative cleavage of C–C bonds of 1,2-diols to ketones: electrochemistry vs thermochemistry. Org. Chem. Front., 9, 2664-2670.
