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JNK/Bid信号通路及其在脑缺血再灌注损伤中的作用研究进展. (2026). 环球医学研究, 3(2), 31-34. https://doi.org/10.62836/medicine.v3i2.1086
Copyright (c) 2026 陈昀
This work is licensed under a Creative Commons Attribution 4.0 International License.
JNK/Bid信号通路及其在脑缺血再灌注损伤中的作用研究进展
陈昀
浙江中医药大学，浙江杭州
摘要：脑缺血损伤是由于脑组织血液灌注减少而使细胞发生损伤，导致器官或系统功能障碍。缺血后恢复血供，可能出现脑组织二次损伤，即为脑缺血再灌注损伤。JNK/Bid信号通路在该损伤中有重要作用， 可介导神经炎症、细胞凋亡与氧化应激等。关于神经炎症，该通路促使小胶质细胞向M1型极化，分泌产生炎症因子和自由基，介导炎症反应，诱发细胞凋亡。JNK信号通路在氧化应激等条件下可通过Bid-Bax 介导的线粒体途径促进线粒体外膜通透性增加，诱导CytC释放，进而形成凋亡小体并激活caspase-9依赖的caspase级联反应，引起caspase依赖的细胞凋亡。本文就JNK/Bid信号通路及其与脑缺血再灌注的关系进行系统分析研究。
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[4] YANG J, DO-UMEHARA H C, ZHANG Q, et al. miR-221- 5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury [J]. Front Immunol, 2021, 12: 700933.
[5] NAKANO R, NAKAYAMA T, SUGIYA H. Biological Properties of JNK3 and Its unction in eurons, Astrocytes, Pancreatic β-Cells and Cardiovascular Cells [J]. Cells, 2020,9(8).
[6] 翟大勇,闫玲,杨福愉.促细胞凋亡因子Bid蛋白的研究进展[J].生物物理学报,2001,(03):435-40.
[7] 尹智勇, 杨俊元, 祁宏.Bcl-2 蛋白质家族调控细胞凋亡机制的研究进展[J]. 信阳师范学院学报( 自然科学版),2017,30(02):340-4.
[8] 王江,魏晓丽,张爱华,等.Bax/Bak蛋白在凋亡通路中的调控与激活机制[J].生命的化学,2017,37(06):952-7.
[9] PRAKASAM A, GHOSE S, OLEINIK N V, et al. JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1 [J]. Cell Death Dis, 2014, 5(7): e1358.
[10] DENGY, REN X, YANG L, et al. A JNK-dependent pathway is required for T alpha-induced apoptosis [J]. Cell, 2003, 115(1): 61-70.
[11] MAKINWA Y, LUO Y, MUSICH P R, et al. Canonical and oncanonical unctions of the BH3 Domain Protein Bid in Apoptosis, Oncogenesis, Cancer Therapeutics, and Aging [J]. Cancers (Basel), 2024, 16(12).
[12] 邹倩倩, 周盼盼, 李毅乐, 等. 中医药调控氧化应激机制抗脑缺血再灌注损伤的研究进展[J]. 世界中医药,2025,20(19):3554-63.
[13] NI H M, CHEN X, SHI Y H, et al. Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha- induced liver injury in adult and embryonic mice [J]. J Biol Chem, 2009, 284(7): 4373-82.
[14] NEITEMEIER S, JELINEKA, LAINO V, et al. BID links ferroptosis to mitochondrial cell death pathways [J]. Redox Biol, 2017, 12: 558-70.
[15] CHEN Y, FENG X, HU X, et al. Dexmedetomidine Ameliorates Acute Stress-Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway [J]. Oxid Med Cell Longev, 2018, 2018: 4035310.
[16] 任靓明,田红旗.炎症因子及其抑制剂对脑缺血再灌注损伤作用的研究进展[J].中国医药导报,2021,18(12):61-4.